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Pernar CH, Parmigiani G, Giovannucci EL, Rimm EB, Tyekucheva S, Loda M, Finn SP, Vander Heiden MG, Fiorentino M, Ebot EM, Mucci LA

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In these studies that demonstrate exercise induced Nrf2 activation in peripheral tissues like nervous tissue, PBMCs, and lung tissue, and the current investigation, it is unlikely that superoxide and hydrogen peroxide are viable secondary messenger signaling candidates given their half-life and concentration of extracellular enzymes capable of quenching these signals